Enjoy our 4-star luxury hotel in Manchester - the Macdonald Manchester Hotel & Spa. One of the largest hotels in the city, our modern hotel is located a short walk from Piccadilly train station and within easy reach of major motorways making it an ideal place to base yourself when visiting Manchester. Our hotel boasts 338 comfortable rooms, excellent dining, a bar, spa with lots of great treatments, state-of-the-art gym and flexible function rooms, ideal for meetings, weddings and other occasions.